I've reinstalled two times now. At the last reinstall I renamed the profile folder and started a new save game. I found out that the base game works fine, and that it starts crashing after installing World Adventures.

I'm going to do one last reinstall skipping WA, start fresh over again and let Amibitions generate the profile directory, like you suggest. For extra thoroughness, I'm going to seek out left over registry entries as well.

*edit*
No dice. Base game works fine, Ambitions makes the game crash around the 15 minute mark (like WA)

I'm still experiencing crashes after the latest patch and then Ambitions on XP (32-bit), even after trying every suggestion. It's incredibly frustrating that it seems completely random and neither the event log nor the game's crash logs tell anything useful.

Running without mods or a completely new profile directory doesn't help either. And as no other games I play ever crash, I can't blame it on misconfiguration or hardware error.

Does anyone else have a suggestion, other than waiting for a patch that hopefully solves this?

I've got the same problem. It runs fine without mods, so I'm going to start taking out mods one by one, starting with the global ones.

*edit*
It started working when I took out NRaas' Supercomputer. Going to put other mods back in and see if it keeps working

*edit 2*
The game loads fine with all other mods